abcam ab115759abcam白介23抗体Anti-IL23 antibody

Properties

• FormLiquid
• Storage instructionsStore at +4°C.
• Storage bufferPreservative: 0.02% Sodium azide
  Constituent: 99% PBS
• Concentration50 µg at 1 mg/ml
  
  Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Tumor immunology
  • Cytokines
  • Interleukins

  • Immunology
  • Innate Immunity
  • Cytokines
  • Interleukins

Applications

Target

• FunctionAssociates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
• Tissue specificitySecreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells （at protein level）.
• Sequence similaritiesBelongs to the IL-6 superfamily.
• Developmental stageExpressed by newborns dendritic cells.
• Cellular localizationSecreted. Secreted upon association with IL12B.

Target information above from: UniProt accession Q9NPF7 The UniProt Consortium
The Universal Protein Resource （UniProt） in 2010
Nucleic Acids Res. 38:D142-D148 （2010）.

Information by UniProt
• Database links
  • Entrez Gene: 51561 Human
  • Entrez Gene: 83430 Mouse
  • Entrez Gene: 83430 Mouse
  • Omim: 605580 Human
  • SwissProt: Q9NPF7 Human
  • SwissProt: Q9EQ14 Mouse
  • SwissProt: Q9EQ14 Mouse
  • Unigene: 98309 Human

  • Unigene: 382212 Human
  • Unigene: 98309 Human
  • Unigene: 125482 Mouse
  • Unigene: 125482 Mouse

  see all

• Alternative names
  IL 23 antibodyIL 23A antibodyIL-23 subunit alpha antibody

  IL-23-A antibodyIL-23p19 antibodyIL23 antibodyIl23a antibodyIL23A_HUMAN antibodyIL23P19 antibodyInterleukin 23 alpha subunit p19 antibodyInterleukin 23 p19 subunit antibodyInterleukin-23 subunit alpha antibodyInterleukin-23 subunit p19 antibodyJKA3 induced upon T cell activation antibodyMGC79388 antibodyP19 antibodySGRF antibody

  see all

Anti-IL23 antibody images

• 

  Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）
  Human Kidney （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
• 

  Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）
  Mouse Brain （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
• 

  Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）
  Mouse Kidney （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
• 

  Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）
  Mouse Liver （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.