Also known as: Pan Macrophage Marker
Clone: BM8
Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximay 125 kDa transmembrane protein. The F4/80 antigen is expressed by a majority of mature macrophages and is the best marker for this population of cells. However, other cell types such as Langerhans cells and liver Kupffer cells have been reported to express this antigen. Expression of F4/80 commences during early myeloid development and is upregulated on all BM cells stimulated in vitro with M-CSF. It has been shown that some cytokines downregulate the expression of F4/80 resulting in lack of F4/80 antigen on a subpopulation of macrophages, especially in the lymphoid microenvironment in vivo
| Host | Rat |
| Isotype | IgG2a, kappa |
| Reactivity | Mouse |
| Conjugate | PE |
| Laser | Blue Laser, Green Laser, Yellow-Green Laser |
| Emit | 575 nm |
| Excite | 488 - 561 nm |
| Reported Applications | Flow Cytometric Analysis |
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