100-21Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

产品编号:

100-21

别名:

Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor

描述:

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors. Recombinant Human TGF-β1 derived from HEK293 cells is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

氨基酸序列:

ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

来源:

HEK293 cells

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

The ED₅₀ was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

交叉反应:

Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat, Human, Mink, Donkey, N/A, Mouse + Virus

Peprotech重组人TGF-beta1细胞因子Recombinant Human TGF-β1

研究领域:

	血管生成/ 心血管		细胞凋亡
	癌症		免疫系统
	炎症		增殖
	干细胞及分化		TGF超家族
	创伤修复		过敏

原产国:

USA